Caution is warranted and therapeutic concentration monitoring is recommended for antiarrhythmics when coadministered with CRIXIVAN. Vorapaxar: CYP3A4 Inhibitors Strong may increase the serum concentration of Vorapaxar. HIV-1 infection to others. Udenafil: CYP3A4 Inhibitors Strong may increase the serum concentration of Udenafil.
Tofacitinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Tofacitinib. Management: Reduce the adult dose of tofacitinib to 5 mg daily in patients receiving strong CYP3A4 inhibitors. DOCEtaxel: CYP3A4 Inhibitors Strong may increase the serum concentration of DOCEtaxel. Management: Avoid the concomitant use of docetaxel and strong CYP3A4 inhibitors when possible. If combined use is unavoidable, consider a 50% docetaxel dose reduction and monitor for increased docetaxel toxicities. Administer with water 1 hour before or 2 hours after a meal. Do not take other medicines unless they have been discussed with your doctor.
Tolterodine: CYP3A4 Inhibitors Strong may increase the serum concentration of Tolterodine. St John's Wort: May increase the metabolism of Protease Inhibitors. Bromocriptine: CYP3A4 Inhibitors Strong may increase the serum concentration of Bromocriptine. Sildenafil dose should not exceed a maximum of 25 mg in a 48-hour period in patients receiving concomitant Crixivan therapy. Use with increased monitoring for adverse events. Indinavir deposition in synovial fluid may have resulted in monoarthritis in a patient.
Some MEDICINES MAY INTERACT with indinavir. Advisory Council OARAC. NIH. National Institutes of Health "Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Dubé MP, Johnson DL, Currier JS et al. Protease inhibitor-associated hyperglycaemia. Lancet. Tadalafil dose should not exceed a maximum of 10 mg in a 72-hour period in patients receiving concomitant CRIXIVAN therapy. Use with increased monitoring for adverse events.
Valbenazine: CYP3A4 Inhibitors Strong may increase the serum concentration of Valbenazine. Management: Reduce the valbenazine dose to 40 mg daily when combined with strong CYP3A4 inhibitors. Midazolam is extensively metabolized by CYP3A4. Co-administration with Crixivan with or without ritonavir may cause a large increase in the concentration of this benzodiazepine. No drug interaction study has been performed for the co-administration of Crixivan with benzodiazepines. Based on data from other CYP3A4 inhibitors, plasma concentrations of midazolam are expected to be significantly higher when midazolam is given orally. Therefore Crixivan should not be co-administered with orally administered midazolam see whereas caution should be used with co-administration of Crixivan and parenteral midazolam. Data from concomitant use of parenteral midazolam with other protease inhibitors suggest a possible 3-4 fold increase in midazolam plasma levels. Use with caution. May make these conditions worse. Prophylaxis should be initiated immediately, preferably within hours after exposure. Spontaneous bleeding episodes have been reported in hemophiliac patients while receiving protease inhibitors. No causal relationship has been established, however, hemophiliacs should be monitored closely for bleeding during protease inhibitor therapy. Agouron Pharmaceuticals, La Jolla, CA: Personal communication. This helps indinavir work better. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Cmin for a 200-mg ritonavir dose. Tell your doctor if you have ever had any of the conditions listed above. Etizolam: CYP3A4 Inhibitors Strong may increase the serum concentration of Etizolam. Management: Consider use of lower etizolam doses when using this combination; specific recommendations concerning dose adjustment are not available. Monitor clinical response to the combination closely. Particular caution should be used when prescribing sildenafil, tadalafil, or vardenafil in patients receiving indinavir.
Ivacaftor: CYP3A4 Inhibitors Strong may increase the serum concentration of Ivacaftor. Management: Ivacaftor dose reductions are required; consult full monograph content for specific age- and weight-based recommendations. Advise patients that if a dose is missed, take the next dose at regularly scheduled time. 1 Do not take a double dose to make up for the missed dose. Some medications are moved by pumps into cells. Marijuana might make these pumps less active and increase how much of some medications get absorbed by the body. This might increase the side effects of some medications. Noor MA, Lo JC, Mulligan K, Schwarz JM, Halvorsen RA, Schambelan M, Grunfeld C "Metabolic effects of indinavir in healthy HIV-seronegative men. Concomitant use of trazodone and Crixivan may increase plasma concentrations of trazodone. Adverse events of nausea, dizziness, hypotension and syncope have been observed following coadministration of trazodone and ritonavir. If trazodone is used with a CYP3A4 inhibitor such as Crixivan, the combination should be used with caution and a lower dose of trazodone should be considered. ZERIT may be taken with or without food. Consider alternative antiretroviral therapy to avoid increases in quetiapine drug exposures. People using this may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk ofside effects. Careful monitoring by your doctor may decrease your risk. Moderate. These medicines may cause some risk when taken together. What are the ingredients of ONGLYZA? Take this medicine with a full glass of water. Included as part of the PRECAUTIONSsection. Kopp JB, Miller KD, Mican JA, et al. "Crystalluria and urinary tract abnormalities associated with indinavir. champix
Patients with renal or hepatic impairment should not be given colchicine with Crixivan. ONGLYZA, a total of 4751 42. Hyperbilirubinemia reported in patients receiving indinavir; 1 4 17 23 201 because of risk associated with hyperbilirubinemia kernicterus some experts state do not use in neonates. Drug interaction studies were performed with Crixivan and other drugs likely to be coadministered and some drugs commonly used as probes for pharmacokinetic interactions. The effects of coadministration of Crixivan on the AUC, C max and C min are summarized in effect of other drugs on indinavir and effect of indinavir on other drugs. For information regarding clinical recommendations, see in PRECAUTIONS. Varying degrees of cross-resistance occur among PIs. Rotger M, Taffe P, Bleiber G, et al. "Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia. Concomitant use of fluticasone propionate and Crixivan may increase plasma concentrations of fluticasone propionate. Use with caution. Consider alternatives to fluticasone propionate, particularly for long-term use. Psychiatric side effects have included anxiety and neurosis. Depression has been reported during postmarketing experience. Delavirdine: Delavirdine inhibits the metabolism of indinavir such that coadministration of 400-mg or 600-mg indinavir three times daily with 400-mg delavirdine three times daily alters indinavir AUC, C max and C min see . Indinavir had no effect on delavirdine pharmacokinetics see based on a comparison to historical delavirdine pharmacokinetic data. Anon. HIV seroconversion after occupational exposure despite early prophylactic zidovudine therapy. Lancet. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Delamanid: CYP3A4 Inhibitors Strong may increase the serum concentration of Delamanid. Management: Increase electrocardiogram ECG monitoring frequency if delamanid is combined with strong CYP3A4 inhibitors because the risk for QTc interval prolongation may be increased. Continue frequent ECG assessments throughout the full delamanid treatment period. Medication Guide for a complete list of ingredients in ONGLYZA. While you are taking indinavir, it is important that you drink extra fluids so that you will pass more urine. This will help prevent possible kidney stones. Follow your doctor's instructions carefully about how much fluid to drink. Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. 1 Advise HIV-infected women not to breast-feed. micronase price micronase
The risk may be greater if you smoke. Ascher DP, Lucy MD. Indinavir sulfate renal toxicity in a pediatric hemophiliac with HIV infection. Ann Pharmacother. What are the ingredients in ZERIT? Rietsema WJ. Fever, erythroderma, abdominal pain, and renal failure following initiation of indinavir therapy. Clin Inf Dis. Protease inhibitors may slow down how quickly your liver processes atorvastatin. Cobicistat is also a protease inhibitor. Drospirenone: CYP3A4 Inhibitors Strong may increase the serum concentration of Drospirenone. Do not stop taking any medications without consulting your healthcare provider. Roling J, Schmid H, Fischereder M, Draenert R, Goebel FD "HIV-Associated Renal Diseases and Highly Active Antiretroviral Therapy-Induced Nephropathy. Lomitapide: CYP3A4 Inhibitors Strong may increase the serum concentration of Lomitapide. Temporary may occur. Normal growth should return after treatment has ended. North Chicago, IL; 2012 Feb. If you are taking indinavir with delavirdine and you notice any pain in your side, blood in your urine, nausea, vomiting, or diarrhea, contact your healthcare professional. If your doctor prescribes these medicines together, it may be necessary to adjust your dose of indinavir. Do not start, stop, or change the dosage of any medicine before checking with them first. Do not skip pills even if you are spotting or bleeding between monthly periods or feel sick to your stomach nausea. Everolimus has rarely caused very serious possibly fatal problems. Tell your doctor right away if you develop signs of problems, such as a change in the amount of urine. In a 1997 postmarketing report, the average time to onset of protease inhibitor PI-related hyperglycemic event was 76 days. However, some cases occurred as early as 4 days after the initiation of therapy. The disorder was serious in 32 out of 83 cases, which included 27 hospitalizations and 5 incidents of diabetic ketoacidosis. Kang-Birken SL, Prichard JG "Paronychia of the great toes associated with protease inhibitors.
HIV protease inhibitor. Clin Pharmacol Ther. Vinorelbine: CYP3A4 Inhibitors Strong may increase the serum concentration of Vinorelbine. Do not have any kind of sex without protection. Always practice safe sex by using a latex or polyurethane condom to lower the chance of sexual contact with semen, vaginal secretions, or blood. Upjohn Company August, 2012. Therefore, get medical help right away if you develop any rash. Consult appropriate product labeling. Boceprevir: May decrease the serum concentration of Protease Inhibitors. Protease Inhibitors may decrease the serum concentration of Boceprevir. Management: Some combinations are not recommended. See full drug interaction monograph for details. Indinavir interacts with many drugs. F. Do not freeze. Canadian labeling: Additional contraindications not in US labeling: Coadministration with atazanavir, rifampin, and St. John wort. Study 028, a double-blind, multicenter, randomized, clinical endpoint trial conducted in Brazil, compared the effects of Crixivan plus zidovudine with those of Crixivan alone or zidovudine alone on the progression to an ADI or death, and on surrogate marker responses. Graves' disease, polymyositis, and Guillain-Barre syndrome have been reported in the setting of immune reconstitution. Merry C, Barry MG, Ryan M et al. Interaction of sildenafil and indinavir when co-administered to HIV-positive patients. AIDS. Some medications are changed and broken down by the liver. Marijuana might decrease how quickly the liver breaks down some medications. Using marijuana along with some medications that are broken down by the liver might increase the effects and side effects of some medications. Before using marijuana talk to your healthcare provider if you take any medications that are changed by the liver. generic risperdal spray risperdal
Your doctor may adjust your dose if needed. Determined while patients were off dialysis. Dose reduction of rifabutin to half the standard dose consult the manufacturer's product circular for rifabutin and a dose increase of Crixivan to 1000 mg every 8 hours are recommended when rifabutin and Crixivan are coadministered. In vitro phenotypic susceptibilities to indinavir were determined for 38 viral isolates from 13 patients who experienced virologic rebounds during indinavir monotherapy. This drug may make you dizzy or drowsy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid beverages. ZERIT is used alone. Changes in body fat have been seen in some patients taking antiretroviral therapy. These changes may include increased amount of fat in the upper back and neck "buffalo hump" breast, and around the trunk. Loss of fat from the legs, arms and face may also happen. The cause and long term health effects of these conditions are not known at this time. Indinavir may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use indinavir with caution. What should I avoid while taking ZERIT? mebeverine cheap australia
Ho TTY, Chan KCW, Wong KH et al. Abnormal fat distribution and use of protease inhibitors. Lancet. Gulnik SV, Suvorov LI, Liu B et al. Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Propafenone: CYP3A4 Inhibitors Strong may increase the serum concentration of Propafenone. Rhame FS, Rawlins SL, Petruschke RA, et al. "Pharmacokinetics of indinavir and ritonavir administered at 667 and 100 milligrams, respectively, every 12 hours compared with indinavir administered at 800 milligrams every 8 hours in human immunodeficiency virus-infected patients.
Carr A "HIV protease inhibitor-related lipodystrophy syndrome. St. John's wort, drugs used to treat such as phenytoin among others. There have been more than 60 reports of acute or chronic human overdosage up to 23 times the recommended total daily dose of 2400 mg with Crixivan. SAXagliptin: CYP3A4 Inhibitors Strong may increase the serum concentration of SAXagliptin. Caucasian 75% with a mean age of 65 years. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. cheap clotrimazole with prescription
Squibb Company September, 2016. Fung HB, Pecini RA, Brown ST, Gropper CA "Indinavir-associated maculopapular eruption. Can Crixivan be taken with other medications? Dutasteride: CYP3A4 Inhibitors Strong may increase the serum concentration of Dutasteride. Saez-Llorens X, Ramilo O. Early experience with protease inhibitors in human immunodeficiency virus-infected children. Axitinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Axitinib. Management: Avoid concurrent use of axitinib with any strong CYP3A inhibitor whenever possible. If a strong CYP3A inhibitor must be used with axitinib, a 50% axitinib dose reduction is recommended. Concomitant use of trazodone and CRIXIVAN may increase plasma concentrations of trazodone. Adverse events of nausea, dizziness, hypotension and syncope have been observed following coadministration of trazodone and ritonavir. If trazodone is used with a CYP3A4 inhibitor such as CRIXIVAN, the combination should be used with caution and a lower dose of trazodone should be considered. Imidafenacin: CYP3A4 Inhibitors Strong may increase the serum concentration of Imidafenacin. Gerberding JL. Management of occupational exposures to blood-borne viruses. N Engl J Med. minti.info losartan
Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Cotton D, moderator. The use of protease inhibitors. AIDS Clin Care. Oxybutynin: CYP3A4 Inhibitors Strong may increase the serum concentration of Oxybutynin. ONGLYZA did not increase over time. Absorption may be decreased in patients who have diarrhea or vomiting; monitor closely and consider use of an antiemetic. If severe, consider use of an alternative antiprotozoal. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; back, flank, or side pain; bloody or cloudy urine; change in the amount of urine produced; changes in appetite; chest, jaw, or arm pain; chills; confusion; dark urine; depression; fainting; fever; heartburn; ingrown toenails; joint pain; loss of appetite; numbness of the mouth; one-sided numbness or weakness; pain while urinating; pale stools; red, swollen, blistered, or peeling skin; severe or persistent stomach pain or upset; shortness of breath; speech problems; sudden, unusual sweating; swelling of the stomach; unusual hair loss; unusual paleness; unusual tiredness or weakness; unusually dry skin; vision changes; yellowing of the skin or eyes. Gilead Sciences. Emtriva emtricitabine capsules and oral solution prescribing information. Foster City, CA; 2012 Jul. Concomitant use of parenteral midazolam with Crixivan may increase plasma concentrations of midazolam. Pollard RB. Use of proteinase inhibitors in clinical practice. Pharmacotherapy. Changes in body may occur while you are taking this medication such as increased fat in the upper back and areas, decreased fat in the arms and legs. The cause and long-term effects of these changes are unknown. Discuss the risks and benefits of treatment with your doctor, as well as the possible use of to reduce this side effect. Tasimelteon: CYP3A4 Inhibitors Strong may increase the serum concentration of Tasimelteon. Spooner KM, Lane HC, Masur H. Guide to major clinical trials of antiretroviral therapy administered to patients infected with human immunodeficiency virus. Clin Infect Dis. Cases of acute spontaneous bleeding in hemophiliacs may be associated with protease inhibitors in general.
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Your name may need to be listed on an antiviral pregnancy registry when you start using this medication. To prevent pregnancy, use an additional form of birth control eg, condoms until your next menstrual period. ONGLYZA or placebo in addition to their current dose of TZD. tolterodine patch
ARIPiprazole Lauroxil: CYP3A4 Inhibitors Strong may increase serum concentrations of the active metabolites of ARIPiprazole Lauroxil. Management: Please refer to the full interaction monograph for details concerning the recommended dose adjustments. Take indinavir with a full glass 8 ounces of water or skim milk. You may also drink juice, coffee, or tea with this medicine. Drink at least 6 glasses of water each day to prevent kidney stones while you are taking indinavir. GuanFACINE: CYP3A4 Inhibitors Strong may increase the serum concentration of GuanFACINE. Management: Reduce the guanfacine dose by 50% when initiating this combination.
Kopp JB, Miller KD, Mican JM et al. Crystalluria and urinary tract abnormalities associated with indinavir. Ann Intern Med. ViiV Healthcare. Lexiva fosamprenavir calcium tablets and oral suspension prescribing information. Research Triangle Park, NC; 2012 Feb. Patients with asymptomatic severe leukocyturia should be followed closely and monitored frequently with urinalyses. Further diagnostic evaluation may be warranted, and discontinuation of Crixivan should be considered in all patients with severe leukocyturia. Genentech USA. Invirase saquinavir mesylate capsules and tablets prescribing information. South San Francisco, CA; 2012 Feb. droxia
Gulick RM, Mellors JW, Havlir D et al. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Engl J Med. Pediatric patients: Limited data indicate pharmacokinetic profile not comparable to that reported in adults. Follow your doctor's instructions about any restrictions on food, beverages, or activity. Your skin and the whites of your eyes may turn yellow. You may have abdominal pain.